Ted Dombrowski’s decadent sandwich takes the title for the greatest thing between sliced bread. The star player is the Wagyu beef, fresh from top rounds, rubbed with house seasoning, roasted medium-rare, sliced, and then topped with caramelized onions and sautéed mushrooms on locally baked, blue-cheese aïoli-slathered bread. Hit with a panini press just long enough to heat it through, it’s a sandwich that satisfies your appetite but stays on your mind. 334 East Bay St., (843) 577-0094, www.tedsbutcherblock.com